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154,155 These opioid agonists also disrupt the endocrine system: methadone has been shown to disturb the hypothalamic pituitary gonadal axis, 156,157 and buprenorphine “has not been adequately studied in respect to its long-term effects on the hypothalamic-pituitary-adrenal (HPA) axis” as noted in a 2018 literature review by Varma et al

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Glutathione is well tolerated at standard subcutaneous doses, and the most common complaint is exactly what you would predict from the chart: larger draws produce more site soreness and occasional redness, which is why splitting a weekly total into smaller injections is easier to live with than concentrating it