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The activation of β3-adrenergic receptors (ADRB3) and the downstream signaling pathways, including protein kinase A (PKA) and AMP-activated protein kinase (AMPK), further supports the role of quercetin in promoting energy expenditure
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The well-known signaling mechanisms involve protein–protein interactions, allosteric changes induced by the binding of ligands, proteolytic processing, and chemical modifications such as acylation, acetylation, alkylation, and phosphorylation of proteins
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