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Although the key rate-limiting enzyme in the de novo synthesis pathway of BH4 is GCH1 in most cells, PTPS has also been considered as a rate-limiting enzyme in certain types of cells, especially in human liver cells (35)
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How B12 Affects Energy and Mental Clarity One of the most common reasons people seek B12 for fatigue is that deficiency symptoms can often mimic those of chronic tiredness or burnout
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