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The study demonstrated that this chemotype achieves selective NNMT inhibition while remaining membrane-permeable — a critical property because NNMT operates intracellularly
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Activation of NF2 can promote the downregulation of E3 ubiquitin ligase CRL4 DCAF1 , suppress Lats1/2 degradation in the hippocampal pathway, thereby promote YAP phosphorylation [227]
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