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All these modifications observed with age can drastically affect several drug metabolizing enzymes and mainly, several CYP isozymes that catalyze the metabolism of numerous prescribed drugs ( In conclusion, the restricted experience in the use of most drugs in children and elderly patients, the decline in memory with age along with the increased stress susceptibility and the decreased activity of various hormonal systems, which follow ageing and largely determine the CYP-dependent drug metabolism, are exceptionally important parameters that should be taken into account when designing treatment regimes in pediatric and geriatric patients, in order to provide them with the appropriate drug dosing regimes and assure the optimal effectiveness and restricted adverse reactions of pharmacotherapy

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“Persisters”: survival at the cellular level