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[DOI] [PubMed] [Google Scholar] 19.Yuan M, Breitkopf SB, Yang X, Asara JM

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While invasive and metastatic cells have not specifically been studied for their sensitivity to glutaminolysis inhibition, it has been shown that highly invasive ovarian cancer cells have increased glutamine dependence compared to less invasive cells 181 , and metastatic prostate tumors show increased glutamate availability and dependence on glutamine uptake 93, 182

entering cells and releasing glutathione intracellularly where its most needed