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The FOXO4 peptide in a DRI conformation (D-amino acids in a retro-reversed sequence), henceforth named FOXO4-DRI, competes with FOXO4 for p53 binding in a dose-dependent manner and doing so with higher affinity.
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This leads to endotoxemia due to increased generation of endotoxins by bacteria, which can leave the intestinal tract and reach the liver via the portal system, potentially causing liver injury [68,126,127]
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