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ICD-10 defines residual schizophrenia as a chronic stage of the illness, in which there has been a progression from an early stage with positive psychotic symptoms to a later stage characterized by long-term negative symptoms and impairments, but reduced frequency and severity of positive symptoms [43]

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Receptor proximal assays can include cAMP response measurements, calcium flux assays where applicable, recruitment assays that track pathway engagement, and internalization or trafficking readouts that inform residence and persistence

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