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This hypothesis derives from the fact that drugs, including phenylcyclohexylpiperidine (PCP), cause schizophrenia-like psychotic symptoms in humans by blocking the function of the NMDA receptor, and that such psychotic symptoms are difficult to diagnostically distinguish from schizophrenia (26)
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Thus, employment of a ChiE-specific antibody would help to clarify surface exposure and protein stability, and may therefore contribute to the observed phenotype in the surrogate strain
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