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PMC6073405 ² BPC-157 angiogenic signaling — VEGFR2-Akt-eNOS activation, nitric oxide bioavailability, FAK-paxillin cell-anchoring cascade, anti-cytokine modulation: PMC8275860 ³ TB-4 / TB-500 G-actin sequestration and threshold-saturation mechanism — actin-monomer binding, cytoskeletal mobilization for cell migration, mass-action pharmacodynamics requiring bolus dosing: PubMed 12581423 ⁴ TB-4 Ac-SDKP anti-fibrotic fragment — N-terminal tetrapeptide (fragment 1–4) released by meprin-α and POP processing
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Given the central role of hepatic GSH in systemic GSH homeostasis, four liver disorders (cholestasis, endotoxemia, alcohol and fibrosis) where decreased GSH synthesis may participate in the pathogenesis of liver injury are described in more detail
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