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LCS3 is a Glutathione Disulfide Reductase (GSR) and TXNRD1 Inhibitor - Network of Cancer Research
Additionally, SLC7A11-mediated cystine uptake induces metabolic vulnerabilities, including glucose and glutamine dependencies, creating potential therapeutic targets for inducing ferroptosis in cells by disrupting their redox balance and metabolic homeostasis (Koppula et al., 2021)
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