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They produce and release a variety of vasoactive substances, such as endothelin-1 (ET-1), nitric oxide (NO), prostacyclin, angiotensin 2 (Ang II), vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), as well as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), which regulate vasodilation, platelet aggregation, and monocyte infiltration