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The recent demonstration of the importance of oxidative stress in osteoarthritis places the use of intra-articular antioxidants, namely glutathione and its precursor, as an important interventional strategy for both joint preparation for biologic therapies as well as a powerful ally in viscosupplementation
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285 Studies have also reported that the overexpression of Wnt ligands (Wnt2, Wnt3a, and Wnt5a), Frizzled receptors, and β-catenin in GBM correlates with tumor grade and poor patient outcomes
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