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A study demonstrated that the migratory capacity of melanocytes was altered by the application of miR-211 mimic through the p53-TRPM1/miR-211-MMP9 axis (58)

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The filtrate was concentrated under vacuum and purified by column chromatography (silica gel, 80:18:2 CHCl 3 /CH 3 OH/NH 4 OH) to afford compound 233 (500 mg, 67% over 2 steps) as a yellow solid: 1 H NMR (400 MHz, DMSO-d 6 ): δ 7.31 (d, J=7.54 Hz, 2H), 7.12 (d, J=7.1 Hz, 2H), 6.93 (d, J=7.2 Hz, 1H), 6.88 (d, J=6.8 Hz, 1H), 4.32 (m, 1H), 3.08-3.03 (m, 1H), 2.91-2.86 (m, 1H), 2.77-2.76 (m, 4H), 2.69 (m, 2H), 2.60-2.55 (m, 4H), 2.35-2.31 (m, 2H), 1.82 (s, 6H), 1.58-1.57 (m, 4H), 1.40 (s, 9H)