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While an enzyme-linked immunosorbent assay (ELISA) analysis has failed to identify GPCR aAB in the CSF of ME/CFS patients (Bynke et al., 2020), the presence of serum aAB against the muscarinic acetylcholine receptor M1 (M1R) correlated with impeded receptor binding in a brain PET study, suggesting leakage of aAB across the BBB (Yamamoto et al., 2012)
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These two Sec-tRNA (Ser)Sec isoforms differ from each other by a single 2′- O -methylribose which is located at position 34 and designated as Um34
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