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Moreover, patients with severe fibrostenotic disease, frequent dilation requirements, or inability to discontinue existing therapies may be excluded, such as PPI-naïve, patients typically cannot undergo trials without first demonstrating PPI failure

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Under the conditions of GSH 10 mM and pH 5.3 the drug release from nanogels were 89.2%, which was attributed to the dual-responsive nature of the nanosystem due to breakage of crosslinking and swelling of gels, respectively