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Abbreviations E-selectin, endothelial selectin ECM, extracellular matrix EC, endothelial cells NO, nitric oxide VEGF, vascular endothelial growht factor aFGF and bFGF, acidic and basic fibroblast growth factors HGF, hepatocyte growth factor KDR, kinase insert domain receptor Flt-1, fms-like tyrosine kinase receptor CHC, chronic hepatitis C HCV, hepatitis C virus Ang, angiopoietin ALT, alanine aminotransferase PBC, primary biliary cirhosis PSC, primary sclerosing cholangitis AIH, autoimmune hepatitis HCC, hepatocellular carcinoma Introduction Angiogenesis, the formation of new vascular structures from preexisting ones, occurs in several organs during multiple pathophysiological situations.1 It has become one of the most thoroughly investigated patophysiological phenomena in the last few years because of the key roles it plays in disease pathogenesis and its potential as a therapeutic target