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bitech l carnitine BiotechUSA L‑Carnitine 1000 mg – 30/60 Tablets for Energy – Nicolas Care l carnitine pills
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from humans C07K14/575—Hormones Landscapes Health & Medical Sciences (AREA) Chemical & Material Sciences (AREA) Organic Chemistry (AREA) Life Sciences & Earth Sciences (AREA) Biophysics (AREA) Gastroenterology & Hepatology (AREA) Zoology (AREA) Biochemistry (AREA) Toxicology (AREA) General Health & Medical Sciences (AREA) Genetics & Genomics (AREA) Medicinal Chemistry (AREA) Molecular Biology (AREA) Proteomics, Peptides & Aminoacids (AREA) Endocrinology (AREA) Peptides Or Proteins (AREA) Abstract 本发明公开了一种Cagrilintide的合成方法,包括如下步骤:步骤一,选取Cagrilintide序列的第7‑8位氨基酸作为伪脯二肽Fmoc‑Ala‑Thr(pro‑me‑me)‑OH,以Cagrilintide序列的第10‑11位氨基酸作为伪脯二肽Fmoc‑Ala‑Thr(pro‑me‑me)‑OH,以Cagrilintide序列的第21‑22位氨基酸作为伪脯二肽Fmoc‑Ser‑Ser(pro‑me‑me)‑OH;步骤二,按照氨基酸序列进行偶联反应;步骤三,裂解;步骤四,环化得到Cagrilintide粗品;本发明的方法操作简单、反应速率高、成本低适于规模化生产,且纯度和收率高。 The invention discloses a method for synthesizing Cagrilintide, comprising the following steps: step 1, selecting the 7-8th amino acid of the Cagrilintide sequence as a pseudo-pro dipeptide Fmoc-Ala-Thr(pro-me-me)-OH, using Cagrilintide The 10-11th amino acid of the sequence is used as the pseudo-pro dipeptide Fmoc-Ala-Thr(pro-me-me)-OH, and the 21-22nd amino acid of the Cagrilintide sequence is used as the pseudo-pro dipeptide Fmoc-Ser-Ser (pro -me-me)-OH
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