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It: Stimulates collagen and elastin synthesis Supports extracellular matrix remodeling Helps regulate inflammation pathways Encourages antioxidant defense activity In practical terms, this translates to improved skin density, reduced fine lines, accelerated recovery from UV damage, and a measurable increase in skin firmness over 8–12 weeks of consistent use

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Hence, the procognitive activity of a molecule in vivo correlates well with its in vitro ability to alter dendritic spine structure and DSD (Moser et al., 1994