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Frontiers | Metformin improves intestinal ischemia-reperfusion injury by reducing the formation of mitochondrial associated endoplasmic reticulum membranes (MAMs) and inhibiting ferroptosis in intestinal cells
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They found that chronic PFOS exposure increases atherosclerosis progression by polarizing M1 macrophages, inducing proinflammatory cytokines, and contributing to the progression and instability of arterial plaques, making them more likely to rupture [178]
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