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In humans, IGF-1 deficiency caused by homozygous mutations in the IGF1 causes microcephaly, mental retardation, deafness, and postnatal growth failure, confirming the essential role of IGF-1 as a neurotrophic factor [1, 2]
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Multisensory cueing: therapists use visual, tactile, and verbal cues to support speech production, fading cues as the child’s speech improves
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