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In the PD model, DR-AB, an antibody that targets the DR region of the NKA-α subunit, disrupts the cytoplasmic interaction between NKA-α1 and Parkin, promotes Parkin translocation to mitochondria, and enhances mitochondrial autophagy
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The behavior and pharmacodynamic of H 2 O 2 have been ascertained: the initial formation of a gradient between plasma and intracellular water [51] allows its entrance into the erythrocytes, lymphocytes and platelets, but its concentration remains around a few micromoles because it is quickly reduced to H 2 O by free GSH, catalase and GSH-Px [52]
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