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IGF-IR −/− mice, however, precluded studies of IGF-IR actions in the growth plates during postnatal growth
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Although immunohistochemical analyses have found B cell-rich tertiary lymphoid structures in most brains from patients with MS, but not in the two PD patients investigated (92), there is ample evidence for the involvement of B cells, antibodies, and humoral immune effector mechanisms in PD (93–95)
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