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This contrasts with MT1 and MT2 which possess several metal-responsive elements in the gene promoter regions allowing for binding of metal regulatory transcription factor-1 (MTF1) in response to activation by metal ions 91,92
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5-Aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis
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