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Healthy individuals typically have a HOMA2-IR of 1.2, while values of 1.4 or greater suggest insulin resistance and metabolic syndrome
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DBS efficacy has improved with adaptive stimulation protocols 28 and advanced neuroimaging 29 , but existing targets have shown limited success in improving levodopa-resistant freezing of gait and may lead to adverse effects, such as cognitive impairment 26,30
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