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Both in vivo and in vitro studies indicated that IGF-2 activates the IGF-1R and downstream PI3K/AKT signaling pathways, thereby mitigating apoptosis and inflammation, with these effects reversed upon IGF-1R inhibition
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[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Gao Y., Martin N.I., van Haren M.J
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