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Our study also highlighted the sequential expression of nuclear receptors, which punctuate the differentiation program of hepatic progenitors toward mature hepatocytes and demonstrated the interplay between the cytoskeleton and EMC remodeling with hepatocyte maturation and metabolism, altogether leading to an increase in our understanding of hepatocyte differentiation/maturation and the proper use of HepaRG cells in toxicology studies
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Survival statistics were performed on GraphPad Prism using logrank (Mantel–Cox) test
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