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Tobacco smoke and other harmful exposures can inhibit SIRT1 and AMPK activity, thereby weakening PGC-1α-mediated mitochondrial transcriptional programs, leading to reduced mtDNA replication, mitochondrial protein expression, and oxidative phosphorylation capacity (74–76)
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Número de viales:4 viales (resultados no diferenciados)
doi: 10.1152/japplphysiol.00431.2011
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