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doi: 10.1002/art.10577 31 HasegawaHInoueAKohnoMMuraokaMMiyazakiTTeradaMet al
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In rats, P450-mediated metabolism of BDCM (Figure 1) is believed to proceed by the same two pathways established for chloroform: oxidation with phosgene the proposed active metabolite, and reduction with the dichloromethyl free radical proposed as the reactive product (Tomasi et al., 1985
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