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Abbreviations: AFP (alpha-fetoprotein), AST (aspartate aminotransferase), ALP (alkaline phosphatase), ALT (alanine aminotransferase), CA 19.9 (an antigen released by pancreatic cancer cells), CAT (catalase), GPx (glutathione peroxidase), γGT (gamma-glutamyl transferase), GST (glutathione S-transferase), GSH (reduces glutathione), IL-1β (interleukin-1 beta), IL-10 (interleukin-10), LDH (lactate dehydrogenase), MDA (malondialdehyde), Nrf2 (nuclear factor erythroid 2-related factor 2), ROS (reactive oxygen species), SOD (superoxide dismutase), TNF-α (tumor necrosis factor-alpha), ↑ (increase), ↓ (decrease)

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Proteins were then precipitated by the addition of the total sample volume to 4× volume liquid chromatography–mass spectrometry (LC–MS)-grade acetonitrile, as per the SP4 protocol 63 , followed by gentle shaking for 5 min and centrifugation at 3,220 g for 10 min

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