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However, in two recent randomized clinical trials, Skinner et al (109) and Tsakiridis et al (110) reported poorer outcomes for patients with NSCLC treated with metformin in combination with radiotherapy, suggesting that the addition of metformin to radiotherapy did not improve OS in patients with NSCLC and increased toxicities, which contrasts the results of previous studies
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Additionally, some authors emphasize that ketamine should be administered for a short duration and at low doses, with continuous cardiorespiratory monitoring, to balance adequate analgesia with safety in neonates (190, 191)
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