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However, abnormalities in cortico-striatal circuitry have been implicated (Prat et al., 2016), as has dysregulation of several neurotransmitter systems including serotonin, acetylcholine, dopamine, GABA and glutamate (Eissa et al., 2018a)
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TDP-43 mutations including A90V and N267S are observed in both cases of sporadic ALS as well as FTLD whereas R361T was reported in a patient case of fALS and FTLD
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