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In a rat model of acute lung injury, inhaled QU-nanogel provided targeted delivery of quercetin to the lung, attenuated lung inflammation and oxidative damage, and prevented subsequent lung fibrosis as evidenced by down-regulation of inflammatory cytokines (TNF-α, IL-6, and IL-1β) and up-regulation of antioxidant enzymes (SOD, catalase, and heme oxygenase-1)
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SST-14 immunoreactivity is widespread in neuritic Aβ plaques, and SST-deficient mice exhibit an Aβ load up to 1.5-times higher than wild-type mice 60,61
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