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While all eukaryotes are descended from a common ancestor, some now lack subunits of the respiratory chain, and others, such as Giardia muris [56] and Entamoeba histolytica [57], lack mitochondria altogether, instead relying on hydrogenosomes for the anaerobic generation of ATP [58]
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Indeed, the first step of glutathione (γ-Glu–Cys–Gly) synthesis, that is, the condensation of cysteine and on the gamma carboxylic group of glutamate is catalyzed by GCL
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