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Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating Oxidative Stress-Mediated Bone Resorption

Luteolin inhibited the expression of target genes IL-6, IL-12, IL-27, TNF-α, IP-10, IFNβ, CXCL9 (C-X-C motif chemokine ligand 9) in macrophages by inhibiting IRF3 and NF-κB activation ( Supplementary Table 1 )

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Compared to the sham-operated group, DMM operated mice exhibited significantly reduced activity levels, active time, active distance, and average speed