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Additionally, MNAM has a low permeability to the membrane, which is crucial for achieving the desired therapeutic effect of the drug (Neelakantan et al., 2018)
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Pemetrexed was clastogenic in an in vivo micronucleus assay in mouse bone marrow but was not mutagenic in multiple in vitro tests (Ames assay, Chinese Hamster Ovary cell assay)
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