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(12) developed a NP system using PLGA and WGA to deliver L-dopa through the nose, which helps the drug reach the brain directly and avoids the BBB
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Furthermore, a third melatonin-binding site (MT3) has been characterized and identified as the cytosolic enzyme quinone reductase 2 (QR2), a known detoxifying enzyme that reduces menadione and other quinones 26,27
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