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Glutathione is critical for NK cell-mediated immunity - ScienceDirect

Knockout (KO) of FSP1 strongly sensitizes KEAP1 mutant lung cancer cells to ferroptosis [50,98] and shRNA-depletion of FSP1 is sufficient to suppress tumor growth in a KEAP1-deficient lung cancer xenograft model [98]

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For example, unlike the autophagic GPX4 degradation mediated in breast cancer cells by the binding of HSP90 (heat shock protein 90) to GPX4 [71], the upregulation of HSPA5/BIP (heat shock protein family A (Hsp70) member 5) prevents GPX4 degradation through protein-protein interactions in pancreatic cancer cells [77]