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Indeed, diabetic ApoE KO mice demonstrate greater macrophage accumulation with NOX1-, but not NOX4- derived ROS [171,178]

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Limited efficacy of MET monotherapy and rationale for combination approaches While MET inhibitors such as capmatinib and tepotinib have exhibited efficacy in MET Δex14-altered NSCLC, responses in tumors with MET overexpression or MET amplification alone are less consistent