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4.4.3.2 mTOR inhibitors mTOR inhibitors, such as sirolimus, mitigate renal inflammation and fibrosis through the dual inhibition of adaptive and innate immunity
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We speculate that by eliminating senescent cells and improving the microenvironment, FOXO4-DRI activates the proliferation or differentiation of stem Leydig cells, serving as Leydig cell progenitors [34], which in turn leads to improved testosterone secretion
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