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Cth is subsequently hydrolyzed to cysteine, ammonia, and Ξ±-ketobutyrate by CSE [70] (Figure 1)
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Unlike the reducing conditions found within the cytosol of most if not all living cells, extracellular fluids in the body, including blood plasma and extravascular interstitial fluids, are moderately oxidizing and will promote spontaneous oxidation of most free thiols, such as that within Cys
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