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Amantadine also has a reported affinity for the σ1R of 7 µM ([ 3 H]-(+)-SKF-10,047 in rat cerebellum or forebrain homogenates [200]) or 740 µM ([ 3 H]-(+)-pentazocine in permeabilized MDA-MB-468 breast cancer cells [2, 3]), and also has an affinity for the σ2R of 9 µM ([ 3 H]-DTG in membranes prepared from MCF7 breast cancer cells [5, 201])
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