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However, there was an increase in compressive stiffness (Figure 6N) in p14BAPN mice but not tensile stiffness or range of motion (Figures 6O and 6P), which combined with reduced DHI suggests the collapse and compaction of the IVD, consistent with the histological findings showing the degradation of the AF layers
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This combined effect facilitates Aβ plaque buildup, contributing to AD pathogenesis ( Tau hyperphosphorylation: Chronic systemic inflammation and oxidative stress induced by gut microbiome dysbiosis activate tau kinases such as glycogen synthase kinase-3 beta (GSK-3β) and cyclin-dependent kinase 5 (CDK5)
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